AETERNA ZENTARIS INC

CUSIP: 007975303 Class: COM NEW

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 164,672 Value ($000) $14 Avg Close — Range —
Q4 2014
Shares 101,894 Value ($000) $61 Avg Close — Range —
Q4 2013
Shares 11,725 Value ($000) $16 Avg Close — Range —