ANACOR PHARMACEUTICALS INC

CUSIP: 032420101 Class: CMN

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2015
Shares 155,169 Value ($000) $17,529 Avg Close — Range —
Q3 2015
Shares 260,783 Value ($000) $30,697 Avg Close — Range —
Q2 2015
Shares 280,021 Value ($000) $21,682 Avg Close — Range —
Q1 2015
Shares 188,776 Value ($000) $10,921 Avg Close — Range —
Q4 2014
Shares 88,718 Value ($000) $2,861 Avg Close — Range —
Q1 2014
Shares 39,075 Value ($000) $781 Avg Close — Range —
Q3 2013
Shares 10,065 Value ($000) $107 Avg Close — Range —