ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

COMERICA BANK's Holding History (CIK: 0000901541)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 12,416 Value ($000) $502 Avg Close — Range —
Q2 2015
Shares 24,412 Value ($000) $1,404 Avg Close — Range —
Q1 2015
Shares 12,225 Value ($000) $778 Avg Close — Range —
Q4 2014
Shares 24,636 Value ($000) $1,522 Avg Close — Range —
Q3 2014
Shares 12,189 Value ($000) $473 Avg Close — Range —
Q2 2014
Shares 13,206 Value ($000) $455 Avg Close — Range —
Q1 2014
Shares 22,216 Value ($000) $960 Avg Close — Range —
Q4 2013
Shares 21,803 Value ($000) $868 Avg Close — Range —
Q3 2013
Shares 53,499 Value ($000) $2,008 Avg Close — Range —
Q2 2013
Shares 58,541 Value ($000) $1,572 Avg Close — Range —