ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

AXIOM INVESTORS LLC /DE's Holding History (CIK: 0001109147)

Note: Option positions (PUT/CALL) are excluded.

Q1 2015
Shares 34,877 Value ($000) $2,221 Avg Close — Range —
Q4 2014
Shares 26,330 Value ($000) $1,626 Avg Close — Range —