ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 320,611 Value ($000) $12,959 Avg Close — Range —
Q2 2015
Shares 436,239 Value ($000) $25,106 Avg Close — Range —
Q1 2015
Shares 98,536 Value ($000) $6,274 Avg Close — Range —
Q3 2013
Shares 134,081 Value ($000) $5,033 Avg Close — Range —