KYTHERA BIOPHARMACEUTICALS I

CUSIP: 501570105 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 33,684 Value ($000) $2,526 Avg Close — Range —
Q2 2015
Shares 35,168 Value ($000) $2,649 Avg Close — Range —
Q1 2015
Shares 117,066 Value ($000) $5,871 Avg Close — Range —