LEXICON PHARMACEUTICALS INC

CUSIP: 528872104 Class: CMN

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2014
Shares 404,684 Value ($000) $368 Avg Close — Range —
Q4 2013
Shares 37,729 Value ($000) $68 Avg Close — Range —