NANOSPHERE INC

CUSIP: 63009F105 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2014
Shares 76,233 Value ($000) $30 Avg Close — Range —
Q3 2014
Shares 25,100 Value ($000) $14 Avg Close — Range —
Q1 2014
Shares 119,988 Value ($000) $258 Avg Close — Range —
Q4 2013
Shares 39,535 Value ($000) $90 Avg Close — Range —
Q2 2013
Shares 35,688 Value ($000) $110 Avg Close — Range —