OREXIGEN THERAPEUTICS INC

CUSIP: 686164104 Class: COMMON STOCK

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2015
Shares 389,366 Value ($000) $3,049 Avg Close — Range —
Q4 2013
Shares 123,285 Value ($000) $694 Avg Close — Range —