PAIN THERAPEUTICS INC

CUSIP: 69562K100 Class: CMN

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 20,443 Value ($000) $35 Avg Close — Range —
Q4 2014
Shares 40,369 Value ($000) $82 Avg Close — Range —
Q2 2014
Shares 101,170 Value ($000) $582 Avg Close — Range —
Q1 2014
Shares 55,059 Value ($000) $303 Avg Close — Range —
Q4 2013
Shares 29,498 Value ($000) $143 Avg Close — Range —