POZEN INC

CUSIP: 73941U102 Class: COMMON STOCK

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2015
Shares 90,359 Value ($000) $617 Avg Close — Range —
Q3 2015
Shares 16,430 Value ($000) $96 Avg Close — Range —
Q2 2015
Shares 188,733 Value ($000) $1,946 Avg Close — Range —
Q1 2015
Shares 37,626 Value ($000) $290 Avg Close — Range —
Q4 2014
Shares 152,144 Value ($000) $1,217 Avg Close — Range —
Q3 2014
Shares 15,105 Value ($000) $111 Avg Close — Range —
Q2 2014
Shares 75,480 Value ($000) $629 Avg Close — Range —
Q1 2014
Shares 145,874 Value ($000) $1,167 Avg Close — Range —
Q4 2013
Shares 273,144 Value ($000) $2,196 Avg Close — Range —
Q3 2013
Shares 11,005 Value ($000) $63 Avg Close — Range —