SANTARUS INC

CUSIP: 802817304 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2013
Shares 17,775 Value ($000) $568 Avg Close — Range —
Q3 2013
Shares 189,015 Value ($000) $4,267 Avg Close — Range —
Q2 2013
Shares 140,775 Value ($000) $2,963 Avg Close — Range —