SENOMYX INC

CUSIP: 81724Q107 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2016
Shares 41,752 Value ($000) $178 Avg Close — Range —
Q1 2016
Shares 10,314 Value ($000) $27 Avg Close — Range —
Q4 2015
Shares 24,121 Value ($000) $91 Avg Close — Range —
Q3 2015
Shares 23,508 Value ($000) $105 Avg Close — Range —