TARGACEPT INC

CUSIP: 87611R306 Class: CMN

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2014
Shares 137,256 Value ($000) $361 Avg Close — Range —
Q3 2014
Shares 87,600 Value ($000) $222 Avg Close — Range —
Q2 2014
Shares 82,261 Value ($000) $371 Avg Close — Range —
Q1 2014
Shares 63,454 Value ($000) $302 Avg Close — Range —
Q4 2013
Shares 116,775 Value ($000) $484 Avg Close — Range —
Q3 2013
Shares 180,420 Value ($000) $958 Avg Close — Range —
Q2 2013
Shares 150,423 Value ($000) $642 Avg Close — Range —