THRESHOLD PHARMACEUTICAL INC

CUSIP: 885807206 Class: CMN

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q2 2016
Shares 39,350 Value ($000) $25 Avg Close — Range —
Q1 2016
Shares 212,242 Value ($000) $98 Avg Close — Range —
Q4 2015
Shares 534,020 Value ($000) $256 Avg Close — Range —
Q4 2013
Shares 50,285 Value ($000) $235 Avg Close — Range —