ZOGENIX INC

CUSIP: 98978L105 Class: CMN

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2014
Shares 34,666 Value ($000) $47 Avg Close — Range —
Q2 2014
Shares 208,559 Value ($000) $419 Avg Close — Range —
Q1 2014
Shares 84,044 Value ($000) $239 Avg Close — Range —
Q4 2013
Shares 13,007 Value ($000) $45 Avg Close — Range —