ALCOBRA LTD

CUSIP: M2239P109 Class: SHS

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q2 2017
Shares 22,300 Value ($000) $25 Avg Close — Range —
Q1 2017
Shares 21,600 Value ($000) $25 Avg Close — Range —
Q4 2014
Shares 30,119 Value ($000) $112 Avg Close — Range —